Aminoglutethimide phosphate
Aminoglutethimide phosphate (DL-Aminoglutethimide phosphate) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide phosphate blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide phosphate reduces cortisol levels. Aminoglutethimide phosphate can be used in research on Cushing's syndrome, breast cancer, and other conditions.
For research use only. We do not sell to patients.
- CAS No.: 23734-88-5
- Formula: C13H19N2O6P
- Molecular Weight:330.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Aromatase |
Aminoglutethimide phosphate inhibits human placental microsomal aromatase by targeting cytochrome P-450, preventing the oxygen-dependent conversion of androgens to estrogens[1].
Aminoglutethimide (0.05 mM; duration sufficient to produce complete steroidogenesis inhibition) phosphate completely inhibits steroidogenesis in monolayer cultures of functional adrenal tumour cells by directly targeting steroidogenic enzymes, without altering ACTH-induced cell morphology or glucose consumption[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aminoglutethimide (8 days) phosphate exhibits goitrogenic activity and interferes with thyroid metabolism in intact rats on a low iodine diet, as evidenced by increased thyroid weight and reduced radio-iodine uptake[4].
Aminoglutethimide phosphate induces thyromegaly, reduces thyroxine and di-iodotyrosine production, and increases thyroidal inorganic iodide levels in Rattus norvegicus[4].
Aminoglutethimide phosphate inhibits adrenal steroid biosynthesis in rats and puppies, inducing adrenal hypertrophy, decreased corticosterone production, increased plasma ACTH, and characteristic cortical histological changes[4].
Aminoglutethimide phosphate induces ovarian enlargement in intact rats and potential uterine enlargement in hypophysectomized rats[4].
Aminoglutethimide (large doses) phosphate disrupts ovarian function, halts oestrous cycles, induces sterility, and reduces oestrogen-related uterine weight in intact female rats[4].
Aminoglutethimide (10 mg/kg; i.v.) phosphate is active to inhibit cortisol secretion and block the steroidogenic response to ACTH in dogs[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crlj:CD1(ICR) (male, 7 weeks old)[3]
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Dosage:125 mg/kg/day; 250 mg/kg/day; 500 mg/kg/day
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Administration:p.o.; once daily; 5 days
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Result:Induced cytoplasmic vacuolation in adrenal zona fasciculata cells at 125-500 mg/kg/day, with vacuole membranes staining positive for adipophilin and LAMP-2, increased LAMP-2-positive granules, and Sudan black-positive vacuole contents.
Observed single cell necrosis in zona fasciculata cells at 250-500 mg/kg/day.
Caused 3 of 4 mice to become moribund and require euthanasia on Day 3 at 500 mg/kg/day.
Revealed enlarged lipid droplets, increased primary lysosomes, mitochondrial vacuolation, and enlarged lysosomes containing damaged mitochondria and lamellar bodies in zona fasciculata cells across all doses via electron microscopy.
Chemical Information
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CAS No. 23734-88-5
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Molecular Weight 330.27
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Formula C13H19N2O6P
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SMILES
O=C1NC(C(CC)(CC1)C2=CC=C(C=C2)N)=O.O=P(O)(O)O
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Synonyms
DL-Aminoglutethimide phosphate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Santen RJ, et al. Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981;1(2):95-120. [Content Brief]
[2]. Cocconi G, et al. First generation aromatase inhibitors--aminoglutethimide and testololactone. Breast Cancer Res Treat. 1994;30(1):57-80. [Content Brief]
[3]. Mutsuga M, et al. Aminoglutethimide-induced lysosomal changes in adrenal gland in mice. Exp Toxicol Pathol. 2017;69(7):424-429. [Content Brief]
[4]. Hughss SW, et al. Aminoglutethimide: a "side-effect" turned to therapeutic advantage. Postgrad Med J. 1970;46(537):409-416. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aminoglutethimide phosphate Related Classifications
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