ILKAP - ILK associated serine/threonine phosphatase Gene

Also Known as PP2CD; PPM1O; ILKAP2; ILKAP3; PP2C-DELTA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80895

About ILKAP

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,170,402-238,203,695 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 16 paralogues. Ubiquitous expression in bone marrow (RPKM 11.1), testis (RPKM 10.3) and 25 other tissues.

Summary

The protein encoded by this gene is a protein serine/threonine Phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of Integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

ILKAP Products (1)

mRNA Protein Name
NM_030768.3 NP_110395.1 integrin-linked kinase-associated serine/threonine phosphatase 2C

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11331582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILKAP Protein Structure

PP2C

PP2C: Protein phosphatase 2C (113 - 383)

  • 0
  • 100
  • 200
  • 300
  • 392 a.a.
Protein Preferred Names Protein Names

integrin-linked kinase-associated serine/threonine phosphatase 2C

  • integrin-linked kinase associated phosphatase

ILKAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ILKAP Q9H0C8 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ILKAP Q9H0C8 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ILKAP Q9H0C8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ILKAP Q9H0C8 ILK Homo sapiens Q13418
Y2H
11331582
Intra
ILKAP Q9H0C8 ILK Homo sapiens Q13418
Anti Bait CoIP
11331582
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ILKAP Proteins

Cat. No. Product Name Accession Purity
HY-P76438 ILKAP/PP2C delta Protein, Human (HEK293, His) Q9H0C8 (M1-H392) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06788 ILKAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20040 Ilkap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26543 Ilkap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ILKAP VGNC VGNC:30178
Rattus norvegicus ILKAP RGD RGD:620128
Mus musculus ILKAP MGD MGI:1914694
Canis familiaris ILKAP VGNC VGNC:42002
Macaca mulatta ILKAP VGNC VGNC:73604
Felis catus ILKAP VGNC VGNC:80246
Others ILKAP NCBI