HVEM/TNFRSF14 Protein, Human (HEK293, hFc)

The HVEM/TNFRSF14 Protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-alpha, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizing the TRAF2-TRAF3 E3 ligase pathway, it promotes immune cell survival and differentiation. HVEM participates in bidirectional cell-cell contact signaling and delivers costimulatory signals to T cells in response to TNFSF14/LIGHT ligation. It interacts with CD160 on NK cells, enhancing anti-tumor responses. During bacterial infection, HVEM on epithelial cells responds to CD160, triggering antimicrobial responses. It down-regulates CD28 signaling in activated CD4+ T cells and engages in both cis and trans interactions with BTLA, influencing immune responses. Additionally, HVEM acts as a receptor for Herpes simplex virus 1/HHV-1. HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293, with C-hFc labeled tag. The total length of HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is 164 a.a., with molecular weight of 48.5 kDa.

HVEM/TNFRSF14, a receptor for four distinct ligands, intricately orchestrates a complex network of stimulatory and inhibitory signaling pathways. Ligands, including TNFSF14/LIGHT, homotrimeric LTA/lymphotoxin-alpha, and immunoglobulin superfamily members BTLA and CD160, collectively define this intricate signaling network. Operating through the TRAF2-TRAF3 E3 ligase pathway, HVEM/TNFRSF14 signals to promote immune cell survival and differentiation, playing a pivotal role in bidirectional cell-cell contact signaling between antigen-presenting cells and lymphocytes. Upon TNFSF14/LIGHT ligation, HVEM/TNFRSF14 delivers costimulatory signals to T cells, fostering cell proliferation and effector functions. Interactions with CD160 on NK cells enhance IFNG production and anti-tumor immune responses. In bacterial infections, HVEM/TNFRSF14 acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. Furthermore, HVEM/TNFRSF14, through binding CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune responses. HVEM/TNFRSF14 exhibits both cis and trans interactions with BTLA, playing diverse roles in immune regulation and survival signaling during adaptive immune responses. Additionally, as a receptor for Herpes simplex virus 1/HHV-1, HVEM/TNFRSF14 is implicated in microbial infection.

Human

HEK293

C-hFc

Q92956 (L39-V202)

8764  [NCBI]

LPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWV

48.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.