TNFRSF14 - TNF receptor superfamily member 14 Gene

Homo sapiens

Also known as TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

Gene ID: 8764 | Gene type: protein coding

About TNFRSF14

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:2,554,234-2,563,829 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 538 orthologues, 21 paralogues and is associated with 66 phenotypes. Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues.

Summary

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFRSF14 Products(2)

mRNA	Protein	Name
NM_001297605.2	NP_001284534.1	tumor necrosis factor receptor superfamily member 14 isoform 2 precursor
NM_003820.4	NP_003811.2	tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

TNFRSF14 Protein Structure

TNFR_c6

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 14

CD40-like protein

Recombinant TNFRSF14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7366	HVEM/TNFRSF14 Protein, Human (Sf9, Fc)	Q92956 (L39-K184)	≥95%
HY-P70489	HVEM/TNFRSF14 Protein, Human (164a.a, HEK293, His)	Q92956 (L39-V202)	≥95%
HY-P73106	HVEM/TNFRSF14 Protein, Human (202a.a, HEK293, His)	Q92956 (M1-V202)	≥95%
HY-P73107	HVEM/TNFRSF14 Protein, Human (HEK293, His-Fc)	Q92956 (M1-V202)	≥95%
HY-P78798	HVEM/TNFRSF14 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q92956 (L39-V202)	≥95%
HY-P700452	HVEM/TNFRSF14 Protein, Human (HEK293, hFc)	Q92956 (L39-V202)	≥95%

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Herpetic Whitlow

Herpetic Felon

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14806	TNFRSF14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TNFRSF14	VGNC	VGNC:80387
Macaca mulatta	TNFRSF14	VGNC	VGNC:78585
Canis familiaris	TNFRSF14	VGNC	VGNC:47658
Rattus norvegicus	TNFRSF14	RGD	RGD:1310115
Mus musculus	TNFRSF14	MGD	MGI:2675303
Others	TNFRSF14	NCBI

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