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DSG2/Desmoglein-2 Protein, Human (HEK293, His)

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Based on 1 publication(s) in Google Scholar

DSG2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • DSG2/Desmoglein-2 Protein, Human (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

DSG2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.

Background

Desmoglein-2 (DSG-2) is an essential component of intercellular desmosome junctions, playing a critical role in mediating cell-cell adhesion. Within these junctions, DSG-2 is involved in facilitating the interaction between plaque proteins and intermediate filaments, contributing to the structural integrity and stability of tissues. Notably, DSG-2 forms an interaction with Plakophilin-2 (PKP2), highlighting its involvement in the intricate molecular network responsible for desmosomal assembly and maintenance. This interaction underscores the significance of DSG-2 in ensuring proper cell adhesion and tissue cohesion, emphasizing its role as a key player in the regulation of intercellular connections in various tissues. (Reference: information provided)

Verified Bioactivity

Immobilized Human DSG-2 at 0.5 μg/mL (100μL/Well) on the plate. Dose response curve for Anti-DSG-2 Antibody with the EC50 <19.5 ng/ml determined by ELISA.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-8*His
  • Accession

    Q14126 (A50-G609)

  • Gene ID
    1829  [NCBI]
  • Molecular Construction
    • N-term
    • DSG2 (A50-G609)
      Accession # Q14126
    • 8*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    DSG2; Cadherin Family Member 5; Desmoglein 2; Desmoglein-2; CDHF5; HDGC

  • AA Sequence

    AWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVG

  • Predicted Molecular Mass

    63.6 kDa

  • Molecular Weight

    Approximately 75-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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