1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Cadherins
  5. DSG2
  6. DSG-2/Desmoglein-2 Protein, Human (HEK293, His)

DSG-2/Desmoglein-2 Protein, Human (HEK293, His)

Cat. No.: HY-P77917
COA Handling Instructions

DSG-2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG-2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is 560 a.a., with molecular weight of 75-80 kDa.

For research use only. We do not sell to patients.

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Description

DSG-2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG-2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is 560 a.a., with molecular weight of 75-80 kDa.

Background

Desmoglein-2 (DSG-2) is an essential component of intercellular desmosome junctions, playing a critical role in mediating cell-cell adhesion. Within these junctions, DSG-2 is involved in facilitating the interaction between plaque proteins and intermediate filaments, contributing to the structural integrity and stability of tissues. Notably, DSG-2 forms an interaction with Plakophilin-2 (PKP2), highlighting its involvement in the intricate molecular network responsible for desmosomal assembly and maintenance. This interaction underscores the significance of DSG-2 in ensuring proper cell adhesion and tissue cohesion, emphasizing its role as a key player in the regulation of intercellular connections in various tissues. (

Biological Activity

Immobilized Human DSG-2 at 0.5 μg/mL (100μL/Well) on the plate. Dose response curve for Anti-DSG-2 Antibody with the EC50 <19.5 ng/ml determined by ELISA.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q14126 (A50-G609)

Gene ID
Molecular Construction
N-term
DSG-2 (A50-G609)
Accession # Q14126
His
C-term
Synonyms
Desmoglein-2; HDGC; DSG2; CDHF5; ARVC10; CMD1BB; MGC117036; MGC117037
Molecular Weight

75-80 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

DSG-2/Desmoglein-2 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
DSG-2/Desmoglein-2 Protein, Human (HEK293, His)
Cat. No.:
HY-P77917
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