Cadherin-9/CDH9 Protein, Human (HEK293, His)

Cadherin-9/CDH9 is a calcium-dependent cell adhesion protein that plays a key role in mediating cell adhesion through preferential homologous interactions, promoting self-association between adjacent cells. This emphasizes its importance in cell adhesion and implies a significant contribution to the sorting of heterogeneous cell types. Cadherin-9/CDH9 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-9/CDH9 protein, expressed by HEK293 , with C-His labeled tag.

Cadherin-9/CDH9 protein, part of the calcium-dependent cell adhesion protein family, plays a pivotal role in mediating cellular adhesion. Operating through preferential homophilic interactions, Cadherin-9/CDH9 facilitates self-binding between adjacent cells. This homophilic cadherin engagement underscores its significance in cell adhesion and implies a substantial contribution to the intricate process of sorting heterogeneous cell types. Through its calcium-dependent adhesion properties, Cadherin-9/CDH9 actively participates in establishing selective connections between cells, thereby influencing the dynamic regulation of cellular interactions and contributing to the organization of tissues.

Measured by its binding ability in a functional ELISA. When Recombinant Human Cadherin-9 is immobilized at 1 μg/mL can bind Biotinylated Human Cadherin-6. The ED₅₀ for this effect is <6 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human Cadherin-9 is immobilized at 1 μg/mL can bind Biotinylated Human Cadherin-6. The ED₅₀ for this effect is 5.36 μg/mL.

Human

HEK293

C-His

Q9ULB4-1 (G54-A615)

1007  [NCBI]

Extracellular Domain

GWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGA

Approximately 70-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

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  ≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.