Cadherin-9

Cadherin-9, also known as T1-cadherin and encoded by CDH9, is a classical cadherin whose expression is concentrated in the developing and adult brain, particularly the telencephalon, as well as in kidney, lung, and testis. Like other classical cadherins it forms calcium-dependent homophilic adhesions that link neighboring cells through catenin-cytoskeleton connections, and it has been implicated in neuronal layering, migration, and synaptic development. T1-cadherin expression changes have been reported in thyroid and gastric cancers, where it may modulate adhesion and signaling output. Overall, cadherin-9 remains less well characterized than E-, N-, or VE-cadherin within the family.