Desmocollin-2
Desmocollin-2 (DSC2) is the broadly expressed desmocollin isoform, found in heart as well as in most epithelia and in early development where the stratified isoforms are absent. In cardiac intercalated discs, DSC2 partners with desmoglein-2 to form desmosomes that withstand constant mechanical stress, and it also localizes to the area composita junctions that mix adhesion and gap junction components. Mutations in DSC2 cause arrhythmogenic right ventricular cardiomyopathy, with arrhythmia and fibrofatty myocardial remodeling. Autoantibodies against DSC2 are additionally implicated in IgA pemphigus, and altered DSC2 levels appear in tumor progression.
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Desmocollin-2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
