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Cadherin-10/CDH10 Protein, Human (HEK293, His)

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Cadherin-10/CDH10 is a calcium-dependent cell adhesion molecule in the cadherin family that participates in preferential homophilic interactions and promotes self-association between adjacent cells. This suggests a key role in mediating cell adhesion and may aid in sorting heterogeneous cell types. Cadherin-10/CDH10 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-10/CDH10 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Cadherin-10/CDH10 Protein, Human (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

Cadherin-10/CDH10 is a calcium-dependent cell adhesion molecule in the cadherin family that participates in preferential homophilic interactions and promotes self-association between adjacent cells. This suggests a key role in mediating cell adhesion and may aid in sorting heterogeneous cell types. Cadherin-10/CDH10 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-10/CDH10 protein, expressed by HEK293 , with C-His labeled tag.

Background

Cadherin-10/CDH10 protein, a member of the cadherin family, operates as a calcium-dependent cell adhesion molecule. Functioning through preferential homophilic interactions, Cadherin-10/CDH10 facilitates self-binding between adjacent cells. This homophilic cadherin engagement suggests a pivotal role in mediating cell adhesion and likely contributes to the intricate process of sorting heterogeneous cell types. Through its calcium-dependent adhesion properties, Cadherin-10/CDH10 is instrumental in establishing selective connections between cells, playing a crucial part in the dynamic regulation of cellular interactions and the organization of tissues.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-His
  • Accession

    Q9Y6N8 (G55-A613)

  • Gene ID
    1008  [NCBI]
  • Molecular Construction
    • N-term
    • CDH10 (G55-A613)
      Accession # Q9Y6N8
    • His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    CDH10; Cadherin 10, Type 2 (T2-Cadherin); Cadherin 10; Cadherin 10 Type 2 Isoform C; Cadherin-10; Alternative Protein CDH10; T2-Cadherin; Cadherin 10 Type 2

  • AA Sequence

    GWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGA

  • Predicted Molecular Mass

    67.5 kDa

  • Molecular Weight

    Approximately 70-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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