67-42-5
67-42-5
Chemical Structure
EGTA
- CAS No.: 67-42-5
- Formula:C14H24N2O10
- Molecular Weight:380.35
IUPAC Name: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
InChIKey: DEFVIWRASFVYLL-UHFFFAOYSA-N
SMILES: O=C(O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O
Biological Activity: EGTA is a cell-impermeant specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGTA | 99.89% | EGTA is a cell-impermeant specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages. | ||||||||||||||||||||
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References
- [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [Content Brief]
- [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. [Content Brief]
