Pentetic acid (Synonyms: Diethylenetriaminepentaacetic acid; DTPA)

Name: Pentetic acid
Brand: MedChemExpress
SKU: HY-B1335
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1335 Purity: 99.80%: Data Sheet
COA

SDS
Handling Instructions
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Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide.

For research use only. We do not sell to patients.

Pentetic acid Chemical Structure

CAS No. : 67-43-6

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Pentetic acid:

Pentetic acid-¹³C₅ Get quote
Pentetic acid (Standard) Get quote

3 Publications Citing Use of MCE Pentetic acid

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•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	39.1 μM Compound: DTPA	Cytotoxicity against human HT29 cells after 72 hrs by MTS assay Cytotoxicity against human HT29 cells after 72 hrs by MTS assay	[PMID: 18345610]
HeLa	IC₅₀	264.5 μM Compound: DTPA	Cytotoxicity against human HeLa cells after 72 hrs by MTS assay Cytotoxicity against human HeLa cells after 72 hrs by MTS assay	[PMID: 18345610]
HepG2	IC₅₀	38.3 μM Compound: DTPA	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 29233652]

In Vitro

Pentetic acid (0-100 μM, 16 h) inhibits the secretion of elastase in PAO1 cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[5]

Cell Line:	PAO1
Concentration:	10, 50, 100 μM
Incubation Time:	16 h
Result:	Decreased the expression of lasB gene transcription levels.

Clinical Trial

Molecular Weight

393.35

Formula

C₁₄H₂₃N₃O₁₀

CAS No.

67-43-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (12.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5423 mL	12.7113 mL	25.4227 mL
5 mM	0.5085 mL	2.5423 mL	5.0845 mL
10 mM	0.2542 mL	1.2711 mL	2.5423 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (273 KB) SDS (557 KB)

COA (247 KB) HNMR (111 KB) RP-HPLC (233 KB) MS (197 KB)

Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. Enhanced selective adsorption of lead(II) from complex wastewater by DTPA functionalized chitosan-coated magnetic silica nanoparticles based on anion-synergism. J Hazard Mater. 2022;422:126856. [Content Brief]

[2]. Reddy J D, et al. Preclinical toxicology, pharmacology, and efficacy of a novel orally administered diethylenetriaminepentaacetic acid (DTPA) formulation[J]. Drug Development Research, 2012, 73(5): 232-242.

[3]. Metsärinne S, et al. Biological and photochemical degradation rates of diethylenetriaminepentaacetic acid (DTPA) in the presence and absence of Fe(III). Chemosphere. 2004 Apr;55(3):379-88. [Content Brief]

[4]. FOREMAN H. The effect of diethylenetriaminepentaacetic acid (DTPA) on acceleration of excretion of actinide elements. Health Phys. 1962 Dec;8:735-7. [Content Brief]

[5]. Gi M, et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2014 Dec;58(12):7205-14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5423 mL	12.7113 mL	25.4227 mL	63.5566 mL
	5 mM	0.5085 mL	2.5423 mL	5.0845 mL	12.7113 mL
	10 mM	0.2542 mL	1.2711 mL	2.5423 mL	6.3557 mL

Pentetic acid Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentetic acid67-43-6Diethylenetriaminepentaacetic acid DTPABiochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantsmagnetic adsorbentmetaldyewastewaterInhibitorinhibitorinhibit

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Pentetic acid (Synonyms: Diethylenetriaminepentaacetic acid; DTPA)

Customer Review

Other Forms of Pentetic acid:

Pentetic acid Related Antibodies

3 Publications Citing Use of MCE Pentetic acid

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Pentetic acid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Pentetic acid Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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