1583289-85-3
Chemical Structure
p-SCN-Bn-NOTA trihydrochloride
- CAS No.: 1583289-85-3
- Formula:C20H29Cl3N4O6S
- Molecular Weight:559.89
InChIKey: UJYWTIBZBSADFF-UHFFFAOYSA-N
SMILES: O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl
Biological Activity: p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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p-SCN-Bn-NOTA trihydrochloride | 99.75% | p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Craft JM, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 2012 Jul;39(5):609-16. [Content Brief]
- [2]. Yun M, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Jun 25;7(10):2620-2633. [Content Brief]
