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  4. P-SCN-Bn-NOTA

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors.

For research use only. We do not sell to patients.

P-SCN-Bn-NOTA

P-SCN-Bn-NOTA Chemical Structure

CAS No. : 147597-66-8

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Based on 1 publication(s) in Google Scholar

P-SCN-Bn-NOTA Related Antibodies

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Description

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors[1].

In Vivo

Radioconjugates synthesized with p-SCN-Bn-NOTA (3.7-7.4 MBq per mouse) exhibit selective uptake in CD70-positive PDX tumors in NCG mice, with tumor uptake values ranging from 4 %ID/g to 11 %ID/g depending on the conjugate and time point, and the highest normal tissue uptake observed in the kidneys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

450.51

Formula

C20H26N4O6S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CN1CCN(CC(CC2=CC=C(C=C2)N=C=S)N(CC1)CC(O)=O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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P-SCN-Bn-NOTA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-SCN-Bn-NOTA147597-66-8Drug IntermediateDrug IintermediateCD70anti-CD70 nanobodieskidneysgallium-68PDX modelsCD70-expressing tumorsNCG mouseradiometal chelationCD70-positive tumorsPET/CT imagingInhibitorinhibitorinhibit

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