p-SCN-Bn-NOTA trihydrochloride
Based on 1 Customer Validation
p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 1583289-85-3
- Formula: C20H29Cl3N4O6S
- Molecular Weight:559.89
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RDC Bifunctional Chelator |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1583289-85-3
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Appearance Solid
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Molecular Weight 559.89
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Formula C20H29Cl3N4O6S
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Color White to off-white
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SMILES
O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (178.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Craft JM, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 2012 Jul;39(5):609-16. [Content Brief]
[2]. Yun M, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Jun 25;7(10):2620-2633. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7861 mL | 8.9303 mL | 17.8607 mL | 44.6516 mL |
| 5 mM | 0.3572 mL | 1.7861 mL | 3.5721 mL | 8.9303 mL | |
| 10 mM | 0.1786 mL | 0.8930 mL | 1.7861 mL | 4.4652 mL | |
| 15 mM | 0.1191 mL | 0.5954 mL | 1.1907 mL | 2.9768 mL | |
| 20 mM | 0.0893 mL | 0.4465 mL | 0.8930 mL | 2.2326 mL | |
| 25 mM | 0.0714 mL | 0.3572 mL | 0.7144 mL | 1.7861 mL | |
| 30 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4884 mL | |
| 40 mM | 0.0447 mL | 0.2233 mL | 0.4465 mL | 1.1163 mL | |
| 50 mM | 0.0357 mL | 0.1786 mL | 0.3572 mL | 0.8930 mL | |
| 60 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 80 mM | 0.0223 mL | 0.1116 mL | 0.2233 mL | 0.5581 mL | |
| 100 mM | 0.0179 mL | 0.0893 mL | 0.1786 mL | 0.4465 mL |
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