5-Sulfosalicylic acid dihydrate
Based on 2 publication(s) in Google Scholar
5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity. 5-Sulfosalicylic acid dihydrate has antioxidant activities.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 5965-83-3
- Formula: C7H10O8S
- Molecular Weight:254.21
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-125006
TRi-1 -
HY-W015175R
p-Toluenesulfonic acid monohydrate (Standard) -
HY-W015175
p-Toluenesulfonic acid monohydrate -
HY-B1610
Sodium citrate dihydrate -
HY-B1610I
Sodium citrate dihydrate, for molecular biology -
HY-B1610E
Sodium citrate dihydrate, meets USP testing specifications -
HY-B1610ER
Sodium citrate dihydrate, meets USP testing specifications (Standard) -
HY-B1610H
Sodium citrate dihydrate, United States Pharmacopeia (USP) Reference Standard
Publications Citing Use of MedChemExpress (MCE) 5-Sulfosalicylic acid dihydrate
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Biological Activity
Description
In Vitro
5-Sulfosalicylic acid dihydrate (0.5-4 mM, 24 h) shows a reduction in the viability of MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and HUVEC cells
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Concentration:0.5, 1, 2, 4 mM
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Incubation Time:24 hours
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Result:Showed the viability of 63.3% and 70.4% in MCF-7 and HUVEC control cells respectively at 1 mM 5-sulfosalicylic acid.
Chemical Information
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CAS No. 5965-83-3
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Appearance Solid
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Molecular Weight 254.21
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Formula C7H10O8S
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Color White to off-white
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SMILES
OC1=CC=C(S(=O)(O)=O)C=C1C(O)=O.O.O
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Synonyms
SSA dihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (393.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (393.38 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.9338 mL | 19.6688 mL | 39.3376 mL | 98.3439 mL |
| 5 mM | 0.7868 mL | 3.9338 mL | 7.8675 mL | 19.6688 mL | |
| 10 mM | 0.3934 mL | 1.9669 mL | 3.9338 mL | 9.8344 mL | |
| 15 mM | 0.2623 mL | 1.3113 mL | 2.6225 mL | 6.5563 mL | |
| 20 mM | 0.1967 mL | 0.9834 mL | 1.9669 mL | 4.9172 mL | |
| 25 mM | 0.1574 mL | 0.7868 mL | 1.5735 mL | 3.9338 mL | |
| 30 mM | 0.1311 mL | 0.6556 mL | 1.3113 mL | 3.2781 mL | |
| 40 mM | 0.0983 mL | 0.4917 mL | 0.9834 mL | 2.4586 mL | |
| 50 mM | 0.0787 mL | 0.3934 mL | 0.7868 mL | 1.9669 mL | |
| 60 mM | 0.0656 mL | 0.3278 mL | 0.6556 mL | 1.6391 mL | |
| 80 mM | 0.0492 mL | 0.2459 mL | 0.4917 mL | 1.2293 mL | |
| 100 mM | 0.0393 mL | 0.1967 mL | 0.3934 mL | 0.9834 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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