17455-13-9
Chemical Structure
18-Crown-6-ether
Synonym(s): 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane
- CAS No.: 17455-13-9
- Formula:C12H24O6
- Molecular Weight:264.32
IUPAC Name: 1,4,7,10,13,16-hexaoxacyclooctadecane
InChIKey: XEZNGIUYQVAUSS-UHFFFAOYSA-N
SMILES: O1CCOCCOCCOCCOCCOCC1
Biological Activity: 18-Crown-6-ether is a type of crown ether compound and a specific structure dissociating agent. 18-Crown-6-ether can compete with K+ for binding to G-quadruplexes, disrupting their stable structure to regulate the functions of related systems. 18-Crown-6-ether combines with K+ and other metal ions to achieve precise ion transmembrane transport. 18-Crown-6-ether can act as an "susceptibility substrate" for the multi-drug efflux pump EmrE (a bacterial multidrug resistance transporter), ultimately inhibiting bacterial growth. 18-Crown-6-ether can be used in microcapsule controlled release and the research on developing antibacterial enhancers[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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18-Crown-6-ether | 99.77% | 18-Crown-6-ether is a type of crown ether compound and a specific structure dissociating agent. 18-Crown-6-ether can compete with K+ for binding to G-quadruplexes, disrupting their stable structure to regulate the functions of related systems. 18-Crown-6-ether combines with K+ and other metal ions to achieve precise ion transmembrane transport. 18-Crown-6-ether can act as an "susceptibility substrate" for the multi-drug efflux pump EmrE (a bacterial multidrug resistance transporter), ultimately inhibiting bacterial growth. 18-Crown-6-ether can be used in microcapsule controlled release and the research on developing antibacterial enhancers. | ||||||||||||||||||||
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- [1]. Lilienthal S, et al. Single and Bilayer Polyacrylamide Hydrogel-Based Microcapsules for the Triggered Release of Loads, Logic Gate Operations, and Intercommunication between Microcapsules. ACS Appl Mater Interfaces. 2020 Jul 15;12(28):31124-31136. [Content Brief]
- [2]. Fong C W. Physiology of ionophore transport of potassium and sodium ions across cell membranes: Valinomycin and 18-Crown-6 Ether. International Journal of Computational Biology and Drug Design, 2016, 9(3): 228-246.
- [3]. Brousseau M, et al. 18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE. Biochemistry. 2025 Sep 16;64(18):3956-3970. [Content Brief]
Keywords
