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  3. Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Drug Derivative
  4. NOTA-bis(tBu)ester

NOTA-bis(tBu)ester  (Synonyms: NOTA-bis(t-Butyl ester))

Cat. No.: HY-W250574 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

NOTA-bis (tBu) ester is a derivative of NOTA (HY-134418). NOTA-bis (tBu) ester is radiolabeled with 68Ga to form ZD2-(68Ga-NOTA) after conjugation with ZD2. ZD2-(68Ga-NOTA) can be used for PET imaging studies of pancreatic cancer.

For research use only. We do not sell to patients.

NOTA-bis(tBu)ester

NOTA-bis(tBu)ester Chemical Structure

CAS No. : 1161415-28-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

NOTA-bis(tBu)ester Related Antibodies

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Description

NOTA-bis (tBu) ester is a derivative of NOTA (HY-134418). NOTA-bis (tBu) ester is radiolabeled with 68Ga to form ZD2-(68Ga-NOTA) after conjugation with ZD2. ZD2-(68Ga-NOTA) can be used for PET imaging studies of pancreatic cancer[1].

IC50 & Target[1]

RDC Bifunctional Chelator

 

In Vivo

ZD2-(68Ga-NOTA) (140 μCi (5.3 MBq)-350 μCi (13.0 MBq); i.v.) achieves BxPC3 pancreatic tumor uptake that is at minimum 4.4-fold higher than muscle tissue in athymic nu/nu mice, enabling clear tumor visualization via PET[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

415.52

Formula

C20H37N3O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CN1CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4066 mL 12.0331 mL 24.0662 mL
5 mM 0.4813 mL 2.4066 mL 4.8132 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (251 KB) HNMR (131 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4066 mL 12.0331 mL 24.0662 mL 60.1656 mL
5 mM 0.4813 mL 2.4066 mL 4.8132 mL 12.0331 mL
10 mM 0.2407 mL 1.2033 mL 2.4066 mL 6.0166 mL
15 mM 0.1604 mL 0.8022 mL 1.6044 mL 4.0110 mL
20 mM 0.1203 mL 0.6017 mL 1.2033 mL 3.0083 mL
25 mM 0.0963 mL 0.4813 mL 0.9626 mL 2.4066 mL
30 mM 0.0802 mL 0.4011 mL 0.8022 mL 2.0055 mL
40 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.5041 mL
50 mM 0.0481 mL 0.2407 mL 0.4813 mL 1.2033 mL
60 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
80 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7521 mL
100 mM 0.0241 mL 0.1203 mL 0.2407 mL 0.6017 mL
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NOTA-bis(tBu)ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-bis(tBu)ester1161415-28-6NOTA-bis(t-Butyl ester)Biochemical Assay ReagentsRadionuclide-Drug Conjugates (RDCs)Drug DerivativeDrug derivativeBxPC3 pancreatic tumorsolid-phase chemistry1,4,7-triazacyclononane-1,4,7-triacetic acidCapan-1 pancreatic tumorPETresin-bound ZD2-HApancreatic cancerathymic nu/nu miceGa(III)fibroblast activation proteinInhibitorinhibitorinhibit

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