1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. Adenosine dialdehyde

Adenosine dialdehyde 

Cat. No.: HY-123055
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Adenosine Dialdehyde is a purine nucleoside analogue and is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH) (IC50=40 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.

For research use only. We do not sell to patients.

Adenosine dialdehyde Chemical Structure

Adenosine dialdehyde Chemical Structure

CAS No. : 34240-05-6

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Description

Adenosine Dialdehyde is a purine nucleoside analogue and is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH) (IC50=40 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].

In Vitro

Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition[1].

In Vivo

Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals[2].
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice[2].
Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].

Animal Model: Adult male A/J mice, weighing 20 to 25 g with MNB cells[2]
Dosage: 1.5-2.5 mg/kg
Administration: Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion)
Result: Significantly suppressed murine neuroblastoma tumor growth.
Prolongs the life span of tumor bearing mice.
Did not suppress hematopoiesis when administered by steady state infusion[2].
Molecular Weight

265.23

Formula

C₁₀H₁₁N₅O₄

CAS No.

34240-05-6

SMILES

O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (37.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7703 mL 18.8516 mL 37.7031 mL
5 mM 0.7541 mL 3.7703 mL 7.5406 mL
10 mM 0.3770 mL 1.8852 mL 3.7703 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Adenosine dialdehydeNucleoside Antimetabolite/Analoganti-tumorMNB cellsNucleoside AnalogueInhibitorinhibitorinhibit

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Adenosine dialdehyde
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