CBL-C Proteins
CBL-C, encoded by the CBL3 gene, is the smallest and least studied of the three CBL-family RING E3 ligases, alongside CBL and CBL-b. It retains the hallmark architecture: an N-terminal tyrosine kinase-binding (TKB) domain, a RING finger responsible for ubiquitin transfer with E2s such as UBE2L3 and UBE2D-family enzymes, and a proline-rich tail, although its linker region is shorter than those of CBL and CBL-b. CBL-C is expressed most strongly in kidney and epithelial tissues, and evidence suggests it dampens rather than drives receptor tyrosine kinase downregulation, potentially antagonizing CBL-b function. Recombinant CBL-C is used to study family-specific ligase activity and substrate selectivity.
-
CBL-C Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
