RNF114 Protein, Human

RNF114 Protein, functioning as an E3 ubiquitin-protein ligase, plays a pivotal role in orchestrating diverse cellular processes by promoting the ubiquitination of various substrates. With broad implications, it is involved in the regulation of fundamental biological processes including cell cycle progression, apoptosis, osteoclastogenesis, as well as both innate and adaptive immunity. RNF114 acts as a negative regulator of NF-kappa-B-dependent transcription by facilitating the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3, and potentially TRAF6, thereby influencing immune responses. Additionally, it functions as a negative regulator of T-cell activation and impedes cellular dsRNA responses and interferon production by targeting the MAVS component for proteasomal degradation. Through its ubiquitination of CDK inhibitors, such as CDKN1A, CDKN1B, and CDKN1C, RNF114 stimulates G1-to-S phase transition, suppressing cellular senescence and potentially contributing to spermatogenesis. This multifaceted activity underscores the significance of RNF114 in governing key cellular pathways and processes.