2. Academic Validation
  3. Inhibition of influenza A virus replication by rifampicin and selenocystamine

Inhibition of influenza A virus replication by rifampicin and selenocystamine

  • J Med Virol. 1980;6(2):169-74. doi: 10.1002/jmv.1890060210.
M Hamzehei,  N Ledinko
PMID: 7241092 DOI: 10.1002/jmv.1890060210
Abstract

The effects of selenocystamine, an inhibitor of Influenza Virus RNA-dependent RNA polymerase in vitro activity, in the Antibiotic rifampicin were studied on influenza A/PR/8/34 (HON1) Infection in embryonated eggs. Both drugs completely inhibited hemagglutinating and infective virus yields when added at relatively early times postinfection. Maximal inhibition was produced by apparently noncytotoxic concentrations of 50 microgram of selenocystamine, or of 400 microgram of rifampicin, per egg.

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