Onradivir monohydrate
Onradivir (ZSP1273) monohydrate is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC50 of 0.562 nM. Onradivir monohydrate inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir monohydrate maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir monohydrate can be used for the research of influenza A virus infection.
For research use only. We do not sell to patients.
- CAS No.: 2375241-19-1
- Formula: C22H24F2N6O3
- Molecular Weight:458.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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RNA Polymerase |
Onradivir (0.457-1000 nM; 24 h post-6-hour transfection) monohydrate potently inhibits influenza A virus polymerase activity in HEK293T cells, with a mean IC50 of 0.562 nM[2].
Onradivir (0.17-10,000 nM) monohydrate does not inhibit most tested human kinases at concentrations up to 10,000 nM, with only weak activity against Aurora A kinase (IC50 = 527 nM)[2].
Onradivir (0.0005-100 μM; 2-5 days) monohydrate potently inhibits replication of wild-type, Oseltamivir (HY-13317)-resistant, and Baloxavir (HY-109025A)-resistant influenza A strains in MDCK cells (EC50 0.012-0.063 nM) with high selective index, and shows weak activity against HRV-1B (EC50 7.88 μM) in H1 HeLa cells[2].
Onradivir (48 h post-virus infection) monohydrate potently inhibits replication of highly pathogenic avian influenza H7N9 and H5N6 viruses in MDCK cells, with IC50 values ranging from 0.245-0.777 nM[2].
Onradivir (10 μM; 3 days) monohydrate does not inhibit HCV genotype 1b replicon replication or cause cytotoxicity at concentrations up to 10 μM[2].
Onradivir (0.16-40 μM; 1 min per concentration) monohydrate does not significantly inhibit hERG potassium channel function in CHO cells at concentrations up to 40 μM (IC50 >40 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Onradivir (ZSP1273) (10 mg/kg; p.o.; twice daily; 7 days) monohydrate provides 100% survival when administered 4 h pre-infection, improves survival when administered 48 h post-infection, provides partial survival when administered 72 h post-infection, and extends time to death when administered 96 h post-infection in influenza A virus WSN/33 (H1N1)-infected female BALB/c mice[2].
Onradivir (ZSP1273) (30-100 mg/kg; p.o.; twice daily; 7 days) monohydrate provides 100% survival at 30 mg/kg, and provides high survival with minimal deaths at 100 mg/kg, when administered starting 48 h post-infection in influenza A virus WSN/33 (H1N1)-infected female BALB/c mice[2].
Onradivir (ZSP1273) (25 mg/kg; p.o.; twice daily; 5 days) monohydrate significantly reduces nasal lavage viral load and maintains stable body weight in influenza A virus/California/07/2009 (H1N1)-infected female ferrets when administered starting 4 h pre-infection[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, SPF grade, 6-7 weeks old, 16-18 g, intranasal inoculation with influenza A virus WSN/33 (H1N1))[2]
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Dosage:3 mg/kg (day 5 endpoint); 10 mg/kg (day 3 endpoint; day 5 endpoint); 30 mg/kg (day 5 endpoint)
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Administration:p.o.; twice daily; days 1-2 (day 3 endpoint); days 1-4 (day 5 endpoint)
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Result:Reduced lung viral titers.
Enabled mice in the 30 mg/kg group to begin regaining body weight on day 4.
Enabled mice in the 10 mg/kg group to begin regaining body weight on day 5.
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Animal Model:BALB/c (female, SPF grade, 6-7 weeks old, 16-18 g, intranasal inoculation with influenza A virus WSN/33 (H1N1))[2]
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Dosage:10 mg/kg
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Administration:p.o.; twice daily; 7 consecutive days; first dose at 4 h pre-infection; first dose at 48 h post-infection; first dose at 72 h post-infection; first dose at 96 h post-infection
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Result:Maintained a 100% survival rate through day 14 and prevented significant body weight loss when dosed at 4 h pre-infection.
Improved survival rate compared to vehicle and supported body weight recovery starting after nadir weight loss when dosed at 48 h post-infection.
Resulted in a 25% survival rate.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2375241-19-1
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Molecular Weight 458.46
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Formula C22H24F2N6O3
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SMILES
FC1=CN=C2C(C(C3=NC(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=C(F)C(C6CC6)=N3)=NN2)=C1.O
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Synonyms
ZSP1273 monohydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li J, et al. Onradivir: a novel influenza polymerase inhibitor. Lancet Respir Med. 2025 Jul;13(7):571-573. [Content Brief]
[2]. Chen X, et al. Preclinical Study of ZSP1273, a Potent Antiviral Inhibitor of Cap Binding to the PB2 Subunit of Influenza A Polymerase. Pharmaceuticals (Basel). 2023;16(3):365. Published 2023 Feb 27. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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