1. Anti-infection
  2. Influenza Virus
  3. Baloxavir

Baloxavir (Synonyms: Baloxavir acid; S-033447)

Cat. No.: HY-109025A Purity: 98.92%
Handling Instructions

Baloxavir (Baloxavir acid), derived from the prodrug Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.

For research use only. We do not sell to patients.

Baloxavir Chemical Structure

Baloxavir Chemical Structure

CAS No. : 1985605-59-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 372 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
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100 mg USD 3000 In-stock
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Baloxavir:

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  • Biological Activity

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Description

Baloxavir (Baloxavir acid), derived from the prodrug Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity[1][2].

IC50 & Target

Influenza virus[1] Cap-dependent endonuclease (CEN)[1][2]

In Vitro

The median EC50 values at baseline for Baloxavir (BXA) are 17.96 nM for A/H1N1pdm, 4.48 nM for A/H3N2, and 18.67 nM for type B virus[1].
Baloxavir (BXA) inhibits viral RNA transcription via selective inhibition of cap-dependent endonuclease (CEN) activity in enzymatic assays, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays. Baloxavir shows broad potency against various subtypes of influenza A viruses (H1N2, H5N1, H5N2, H5N6, H7N9 and H9N2). Additionally, serial passages of the viruses in the presence of Baloxavir result in isolation of PA/I38T variants with reduced BXA susceptibility[2].
Baloxavir (BXA) inhibits cap-dependent endonuclease (CEN) and CEN/RdRp activities with IC50 values of 2.5 nM and 1.6 nM, respectively, while low potency (IC50 >40 nM) is observed against RdRp activity[2].
Baloxavir (BXA) has a high inhibitory potency against CEN activity of the tested viral ribonucleoprotein complexes (vRNPs) from influenza A and B viruses with mean IC50 values of 1.4-3.1 nM and 4.5-8.9 nM, respectively, indicating that Baloxavir has broad spectrum activities. Baloxavir shows high potency against influenza A and B viruses with mean EC90 of 0.46 - 0.98 nM and 2.2-3.4 nM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.49

Formula

C₂₄H₁₉F₂N₃O₄S

CAS No.

1985605-59-1

SMILES

O=C1N2[[email protected]](COCC2)([H])N([[email protected]@H]3C4=CC=CC=C4SCC5=C(F)C(F)=CC=C35)N6C1=C(O)C(C=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (103.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0683 mL 10.3415 mL 20.6830 mL
5 mM 0.4137 mL 2.0683 mL 4.1366 mL
10 mM 0.2068 mL 1.0341 mL 2.0683 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.92%

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Keywords:

BaloxavirBaloxavir acid S-033447S033447S 033447S-033447Influenza VirusBXAendonucleasecap-dependentinfluenzadolutegravirRNAtranscriptionfirst-in-classCENreplication;Inhibitorinhibitorinhibit

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Baloxavir
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HY-109025A
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