1. Anti-infection
  2. Influenza Virus
  3. Laninamivir

Laninamivir (Synonyms: R 125489)

Cat. No.: HY-14818 Purity: 99.91%
Handling Instructions

Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.

For research use only. We do not sell to patients.

Laninamivir Chemical Structure

Laninamivir Chemical Structure

CAS No. : 203120-17-6

Size Price Stock Quantity
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].

IC50 & Target

IC50: 0.90 nM (N5), 1.83 nM (p09N1), 3.12 nM (p57N2)[1]

In Vitro

Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1].
Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

346.34

Formula

C₁₃H₂₂N₄O₇

CAS No.

203120-17-6

SMILES

OC[[email protected]@H](O)[[email protected]]([[email protected]@]1([H])[[email protected]@H]([[email protected]](C=C(C(O)=O)O1)NC(N)=N)NC(C)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (14.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8873 mL 14.4367 mL 28.8734 mL
5 mM 0.5775 mL 2.8873 mL 5.7747 mL
10 mM 0.2887 mL 1.4437 mL 2.8873 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

LaninamivirR 125489R125489R-125489Influenza VirusInhibitorinhibitorinhibit

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Product Name:
Laninamivir
Cat. No.:
HY-14818
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