Laninamivir octanoate hydrate
Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
For research use only. We do not sell to patients.
- CAS No.: 1233643-88-3
- Formula: C21H38N4O9
- Molecular Weight:490.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Laninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34[1]
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Dosage:0.2 μmol/kg (95 μg/kg)
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Administration:Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection
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Result:Showed life-prolonging effect in infected model.
Chemical Information
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CAS No. 1233643-88-3
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Molecular Weight 490.55
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Formula C21H38N4O9
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SMILES
CC(N[C@H]1[C@](OC(C(O)=O)=C[C@@H]1NC(N)=N)([H])[C@H](OC)[C@H](O)COC(CCCCCCC)=O)=O.O
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Synonyms
CS-8958 hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Makoto Yamashita, et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92. [Content Brief]
[2]. Hideyuki Ikematsu, et al. Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza. Expert Rev Anti Infect Ther. 2011 Oct;9(10):851-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laninamivir octanoate hydrate Related Classifications
HY-14818C Related Classifications
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