1. Anti-infection
  2. Influenza Virus
  3. Laninamivir octanoate

Laninamivir octanoate (Synonyms: CS-8958)

Cat. No.: HY-14818A Purity: 98.06%
Handling Instructions

Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.

For research use only. We do not sell to patients.

Laninamivir octanoate Chemical Structure

Laninamivir octanoate Chemical Structure

CAS No. : 203120-46-1

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5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
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100 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses[1][2].

In Vitro

Laninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Laninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34[1]
Dosage: 0.2 μmol/kg (95 μg/kg)
Administration: Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection
Result: Showed life-prolonging effect in infected model.
Clinical Trial
Molecular Weight

472.53

Formula

C₂₁H₃₆N₄O₈

CAS No.

203120-46-1

SMILES

CC(N[[email protected]]1[[email protected]](OC(C(O)=O)=C[[email protected]@H]1NC(N)=N)([H])[[email protected]](OC)[[email protected]](O)COC(CCCCCCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (211.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Laninamivir octanoateCS-8958CS8958CS 8958Influenza VirusAnti-influenzaneuraminidaseH3N2H2N2inhaledInhibitorinhibitorinhibit

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Laninamivir octanoate
Cat. No.:
HY-14818A
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