1. Anti-infection
  2. Influenza Virus
  3. Zanamivir


Cat. No.: HY-13210 Purity: 99.92%
Handling Instructions

Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

For research use only. We do not sell to patients.

Zanamivir Chemical Structure

Zanamivir Chemical Structure

CAS No. : 139110-80-8

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10 mM * 1  mL in Water USD 99 In-stock
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10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 192 In-stock
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Based on 4 publication(s) in Google Scholar

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Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

IC50 & Target

IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1]

In Vitro

Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions[2].

In Vivo

Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].

Clinical Trial
Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 33.33 mg/mL (100.30 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0092 mL 15.0462 mL 30.0924 mL
5 mM 0.6018 mL 3.0092 mL 6.0185 mL
10 mM 0.3009 mL 1.5046 mL 3.0092 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Rats: Formulations PO-SC (Zanamivir with SC for p.o.) and PO-C (Zanamivir control solution for p.o.) are administered orally at a Zanamivir dose of 10 mg/kg, and IV-R (reference Zanamivir saline solution for i.v.) is administered i.v. at a dose of 1 mg/kg to rats under conscious condition. Blood samples are collected prior to and at 0.5, 1, 2, 3, 4, 6, 8, and 24 hr after administration. At each sampling point, three rats from each group are sacrificed after blood collection to extract the lungs. The lungs are cleansed with saline after extraction of lungs from the rats through a chest incision. The lungs are then transferred into E-tube and stored in the freezer (-80°C) until analysis. Plasma samples are harvested by centrifugation at 1,500 × g for 10 min and stored at -20°C until analysis. The analysis of Zanamivir in both plasma and lungs is performed using before-mentioned LC-MS/MS method[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.92%

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This equation is commonly abbreviated as: C1V1 = C2V2

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ZanamivirInfluenza VirusAntibioticInhibitorinhibitorinhibit

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