1. Anti-infection
  2. Influenza Virus
    Antibiotic
  3. Zanamivir

Zanamivir 

Cat. No.: HY-13210 Purity: 99.92%
Handling Instructions

Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

For research use only. We do not sell to patients.

Zanamivir Chemical Structure

Zanamivir Chemical Structure

CAS No. : 139110-80-8

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Based on 4 publication(s) in Google Scholar

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Description

Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

IC50 & Target

IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1]

In Vitro

Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

332.31

Formula

C₁₂H₂₀N₄O₇

CAS No.

139110-80-8

SMILES

NC(N[[email protected]@H]1[[email protected]]([[email protected]@]([H])(OC(C(O)=O)=C1)[[email protected]@H]([[email protected]@H](CO)O)O)NC(C)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 33.33 mg/mL (100.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0092 mL 15.0462 mL 30.0924 mL
5 mM 0.6018 mL 3.0092 mL 6.0185 mL
10 mM 0.3009 mL 1.5046 mL 3.0092 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Rats: Formulations PO-SC (Zanamivir with SC for p.o.) and PO-C (Zanamivir control solution for p.o.) are administered orally at a Zanamivir dose of 10 mg/kg, and IV-R (reference Zanamivir saline solution for i.v.) is administered i.v. at a dose of 1 mg/kg to rats under conscious condition. Blood samples are collected prior to and at 0.5, 1, 2, 3, 4, 6, 8, and 24 hr after administration. At each sampling point, three rats from each group are sacrificed after blood collection to extract the lungs. The lungs are cleansed with saline after extraction of lungs from the rats through a chest incision. The lungs are then transferred into E-tube and stored in the freezer (-80°C) until analysis. Plasma samples are harvested by centrifugation at 1,500 × g for 10 min and stored at -20°C until analysis. The analysis of Zanamivir in both plasma and lungs is performed using before-mentioned LC-MS/MS method[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.92%

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Keywords:

ZanamivirInfluenza VirusAntibioticInhibitorinhibitorinhibit

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