Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity

  • Bioorg Med Chem Lett. 2013 Mar 15;23(6):1776-8. doi: 10.1016/j.bmcl.2013.01.051.
Huquan Gao  1 ,  Wenqiang Guo ,  Qiang Wang ,  Lianqing Zhang ,  Meilin Zhu ,  Tianjiao Zhu ,  Qianqun Gu ,  Wei Wang ,  Dehai Li
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
PMID: 23411074 DOI: 10.1016/j.bmcl.2013.01.051
Abstract

A new butenolide isoaspulvinone E (1), together with two known butenolides aspulvinone E (2) and pulvic acid (3) were isolated from the marine-derived fungus, Aspergillus terreus Gwq-48. They showed significant anti-influenza A H1N1 virus activities, with IC50 values of 32.3, 56.9, and 29.1μg/mL, respectively. Moreover, only compound 1 exhibited effective inhibitory activity against H1N1 viral neuraminidase (NA), and docking of two isomers (1-2) into the active sites of NA showed that the E double bond Δ(5(10)) was essential to achieve activity.

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