Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

  • Eur J Med Chem. 2012 Dec:58:361-7. doi: 10.1016/j.ejmech.2012.10.030.
Attila Sipos  1 ,  Gábor Máté ,  Erzsébet Rőth ,  Anikó Borbás ,  Gyula Batta ,  Ilona Bereczki ,  Sándor Kéki ,  István Jóna ,  Eszter Ostorházi ,  Ferenc Rozgonyi ,  Evelien Vanderlinden ,  Lieve Naesens ,  Pál Herczegh
Affiliations
  • 1. Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary. [email protected]
PMID: 23149298 DOI: 10.1016/j.ejmech.2012.10.030
Abstract

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent Antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.