Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

  • Emerg Infect Dis. 2019 Nov;25(11):2108-2111. doi: 10.3201/eid2511.190757.
Emi Takashita ,  Masataka Ichikawa ,  Hiroko Morita ,  Rie Ogawa ,  Seiichiro Fujisaki ,  Masayuki Shirakura ,  Hideka Miura ,  Kazuya Nakamura ,  Noriko Kishida ,  Tomoko Kuwahara ,  Hiromi Sugawara ,  Aya Sato ,  Miki Akimoto ,  Keiko Mitamura ,  Takashi Abe ,  Masahiko Yamazaki ,  Shinji Watanabe ,  Hideki Hasegawa ,  Takato Odagiri
PMID: 31436527 DOI: 10.3201/eid2511.190757
Abstract

In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza Virus isolates should be monitored for baloxavir susceptibility.

Keywords
H3N2; I38T substitution; Japan; antimicrobial resistance; baloxavir; baloxavir acid; baloxavir marboxil; cap-dependent endonuclease inhibitor; family cluster; human-to-human transmission; influenza; influenza A(H1N1)pdm09; influenza virus; polymerase acidic; respiratory infections; viruses; whole-genome sequencing.
Products