1. NF-κB MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling
  2. IKK JNK STAT p38 MAPK ERK
  3. Peramivir

Peramivir  (Synonyms: RWJ-270201; BCX-1812)

Cat. No.: HY-17015A Purity: 98.19%
COA Handling Instructions

Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Peramivir Chemical Structure

Peramivir Chemical Structure

CAS No. : 330600-85-6

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Customer Review

Based on 9 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19[1][2][3].

IC50 & Target

IKK-α

 

STAT3

 

ERK1

 

ERK2

 

In Vitro

Peramivir (0.3125-40 μM, 4 h) has nontoxicity to macrophage[1].
Peramivir (2-10 μM, 6-12 h) inhibits cytokine release in LPS-induced hPBMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: RAW 264.7
Concentration: 0.3125 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 4 h
Result: Showed no apparent toxicity in the peramivir-treated macrophages at concentrations up to 40 μM.
In Vivo

Peramivir (20-60 mg/kg, Intraperitoneal injection, single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury and prolongs the survival in cytokine storm syndrome model mice[1].
Peramivir (75 mg/kg, Intramuscular injection, once a day for 7 days) rescued BALB scid mice from lethal challenge with BR/08 in immunocompromised murine models of infuenza B virus infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cytokine storm syndrome model mice [1]
Dosage: 20 mg/kg, 60 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased 8 cytokines including TNF-a, IFN-a, IFN-γ, chemokines (MCP-1), GM-CSF, IL-1β, IL-6 and IL-12.
Showed less inflammatory cell infiltrations, mild alveolar thickening and less bleeding points or congestion.
Showed significant protective effects to the lung tissues.
Animal Model: Immunocompromised murine models of infuenza B virus infection[2]
Dosage: 75 mg/kg
Administration: Intramuscular injection (i.m.)
Result: Conferred complete protection against lethality, whether it was administered in one (1×), two (2×), or four (4×) doses, with maximum mean weight loss of 10% to 14%.
Resulted in a trend of decreasing virus replication in the nasal cavities and lungs.
Reduced the virus titers and replication.
Clinical Trial
Molecular Weight

328.41

Formula

C15H28N4O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Peramivir
Cat. No.:
HY-17015A
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