2375241-19-1
Chemical Structure
Onradivir monohydrate
Synonym(s): ZSP1273 monohydrate
- CAS No.: 2375241-19-1
- Formula:C22H24F2N6O3
- Molecular Weight:458.46
InChIKey: XUXVTSUIFIUZSZ-MJSCHBGXSA-N
SMILES: FC1=CN=C2C(C(C3=NC(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=C(F)C(C6CC6)=N3)=NN2)=C1.O
Biological Activity: Onradivir (ZSP1273) monohydrate is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC50 of 0.562 nM. Onradivir monohydrate inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir monohydrate maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir monohydrate can be used for the research of influenza A virus infection[1][2].
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Onradivir monohydrate | Onradivir (ZSP1273) monohydrate is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC50 of 0.562 nM. Onradivir monohydrate inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir monohydrate maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir monohydrate can be used for the research of influenza A virus infection. | |||||||||||||||||||||
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- [1]. Li J, et al. Onradivir: a novel influenza polymerase inhibitor. Lancet Respir Med. 2025 Jul;13(7):571-573. [Content Brief]
- [2]. Chen X, et al. Preclinical Study of ZSP1273, a Potent Antiviral Inhibitor of Cap Binding to the PB2 Subunit of Influenza A Polymerase. Pharmaceuticals (Basel). 2023;16(3):365. Published 2023 Feb 27. [Content Brief]
Keywords
