922732-52-3
Chemical Structure
SSM-3
- CAS No.: 922732-52-3
- Formula:C22H32N12O2
- Molecular Weight:496.58
IUPAC Name: 1,1'-((1R,3S,4S,6R)-4,6-bis(4-guanidinophenoxy)cyclohexane-1,3-diyl)diguanidine
InChIKey: MBDMLDIYZDMGFF-USTZCAOPSA-N
SMILES: O([C@@H]1[C@@H](NC(=N)N)C[C@@H](NC(=N)N)[C@H](OC2=CC=C(NC(=N)N)C=C2)C1)C3=CC=C(NC(=N)N)C=C3
Biological Activity: SSM-3 is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 can be used in the research of anthrax and avian influenza[1][2].
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SSM-3 | SSM-3 is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 can be used in the research of anthrax and avian influenza. | |||||||||||||||||||||
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- [1]. Remacle AG, et al. Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. The international journal of biochemistry & cell biology. 2010 Jun;42(6):987-95. [Content Brief]
- [2]. Jiao GS, et al. Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine. Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 26;103(52):19707-12. [Content Brief]
Keywords
