SSM-3
SSM-3 is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 can be used in the research of anthrax and avian influenza.
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- CAS. Nr.: 922732-52-3
- Formel: C22H32N12O2
- Molecular Weight:496.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
SSM-3 (1-25 μM; 3 h) partially inhibits the processing of cell surface anthrax toxin protective antigen PA83 into PA63 in glioma U251 cell line[1].
SSM-3 (10-100 μM; 18-24 h) blocks the intracellular processing of pro-MT1-MMP to mature enzyme in the breast cancer MCF7 cell line expressing an MT1-MMP mutant (MCF-MT1-E240A-FLAG cells), and partially inhibits the intracellular processing and release of TGFβ1 in the fibrosarcoma HT1080 cell line[1].
SSM-3 potently inhibits purified human furin, with an EC50 of 54 nM[1].
SSM-3 (0.01-100 μM; 24 h) exhibits cytotoxicity against mouse macrophage RAW 264.7 cells at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human glioma U251 cells
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Concentration:1, 5, 25 μM
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Incubation Time:3 h
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Result:Partially inhibited PA83 processing.
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Cell Line:RAW 264.7 cell line
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Concentration:0.01, 0.1, 1, 10, 100 μM
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Incubation Time:24 h
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Result:Exhibited cell toxicity at the 100 μM concentration.
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Cell Line:HT1080 cell line, MCF7 cell line (MCF-MT1-E240A-FLAG)
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Concentration:10, 100 μM
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Incubation Time:18, 24 h
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Result:Blocked the intracellular processing of MT1-MMP.
Partially suppressed the TGFβ1 processing and release.
Chemical Information
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CAS. Nr. 922732-52-3
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Molecular Weight 496.58
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Formel C22H32N12O2
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SMILES
O([C@@H]1[C@@H](NC(=N)N)C[C@@H](NC(=N)N)[C@H](OC2=CC=C(NC(=N)N)C=C2)C1)C3=CC=C(NC(=N)N)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Remacle AG, et al. Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. The international journal of biochemistry & cell biology. 2010 Jun;42(6):987-95. [Content Brief]
[2]. Jiao GS, et al. Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine. Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 26;103(52):19707-12. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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