SSM3 tetraTFA hydrate 

SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro^[1][2].

EC50: 54 nM (furin)
Ki: 12 nM (furin)^[1]

SSM3 tetraTFA hydrate is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC₅₀ of 54 nM in vitro cleavage assays and cell-based tests^[2].
SSM3 tetraTFA hydrate (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions^[2].
SSM3 tetraTFA hydrate shows comparable potency against furin (K_i=0.012 μM) and PC6B (K_i=0.004 μM), these compounds preferentially inhibited furin over PACE4 (K_i=0.041 μM) by 2- to 10-fold and over PC7 (K_i=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (K_i=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

979.70

C₃₀H₃₆F₁₂N₁₂O₁₀.1.5H₂O

N=C(N)NC(C=C1)=CC=C1O[[email protected]@H]2[[email protected]](C[[email protected]@H](NC(N)=N)[[email protected]](OC3=CC=C(NC(N)=N)C=C3)C2)NC(N)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.O.[1.5]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Albert G Remacle, et al. Selective and Potent Furin Inhibitors Protect Cells From Anthrax Without Significant Toxicity. Int J Biochem Cell Biol.  [Content Brief]

  [2]. Guan-Sheng Jiao, et al. Synthetic Small Molecule Furin Inhibitors Derived From 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12.  [Content Brief]