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SSM3 tetraTFA 

Cat. No.: HY-110147A
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SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

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SSM3 tetraTFA Chemical Structure

SSM3 tetraTFA Chemical Structure

CAS No. : 2320930-10-5

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Description

SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].

IC50 & Target

EC50: 54 nM (furin)
Ki: 12 nM (furin)[1]

In Vitro

SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC50 of 54 nM in vitro cleavage assays and cell-based tests[2].
SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions[2].
SSM3 tetraTFA shows comparable potency against furin (Ki=0.012 μM) and PC6B (Ki=0.004 μM), these compounds preferentially inhibited furin over PACE4 (Ki=0.041 μM) by 2- to 10-fold and over PC7 (Ki=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (Ki=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP[2].

Molecular Weight

952.66

Formula

C₃₀H₃₆F₁₂N₁₂O₁₀

CAS No.

2320930-10-5

SMILES

N=C(N)NC(C=C1)=CC=C1O[[email protected]@H]2[[email protected]](C[[email protected]@H](NC(N)=N)[[email protected]](OC3=CC=C(NC(N)=N)C=C3)C2)NC(N)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SSM3 tetraTFAOthersfibrosarcomaHT1080gliomaU251breastcarcinomaMCF7cellsfurinInhibitorinhibitorinhibit

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