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Results for "

anthrax

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (4) Furin (2)
By Research Areas:	Infection (7)

6

Inhibitors & Agonists

3

Peptides

2

Inhibitory Antibodies

5

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

Hexa-D-arginine 3 Publications Verification Furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

SSM3 tetraTFA hydrate	Furin	Infection
SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

IN-2-LF	Bacterial	Infection
IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .

Hexa-D-arginine TFA Furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

SSM3 tetraTFA	Furin	Infection
SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

Cat. No.	Product Name	Target	Research Area

Hexa-D-arginine 3 Publications Verification Furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

IN-2-LF	Bacterial	Infection
IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .

Hexa-D-arginine TFA Furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

Cat. No.	Product Name	Target	Research Area

Obiltoxaximab ETI 204	Inhibitory Antibodies	Infection
Obiltoxaximab is a potent anti-protective antigen (PA) monoclonal antibody. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication. Obiltoxaximab can be used in animal‐to‐human dose translation for research of inhalational anthrax .

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

Species:	Human (3) Mouse (2)
Tag:	His (1) Tag Free (1) Fc (3)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

	TEM8/ANTXR1 Protein, Human rHuanthrax toxin receptor 1, His; ANTXR1; ATR; anthrax toxin receptor 1	Human	HEK293
	TEM8/ANTXR1 Protein, Human is a 35-45 kDa Anthrax toxin receptor 1 protein expressed by HEK293 cells. Human Anthrax toxin receptor 1 is a type I membrane protein with an extracellular von Willebrand factor A domain that binds directly to protective antigen (PA). Human Anthrax toxin receptor 1 is also identified as the high-affinity cellular receptor for Seneca Valley Virus (SVV).

	TEM8/ANTXR1 Protein, Human (HEK293, Fc) ANTXR1; ATR; anthrax toxin receptor 1	Human	HEK293
	TEM8/ANTXR1 Protein, multifunctional in cell attachment and migration, interacts with extracellular matrix proteins and the actin cytoskeleton. This engagement mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeleton reorganization and cell spreading, crucial for cellular architecture and motility. TEM8/ANTXR1 also contributes to the angiogenic response in endothelial cells, emphasizing its role in vascular development. In microbial infections, it acts as a receptor for Bacillus anthracis protective antigen (PA), showcasing its dual function in cellular processes and host-pathogen interactions. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TEM8/ANTXR1 Protein, Human (HEK293, Fc) is 321 a.a., with molecular weight of ~69 kDa.

	CMG-2/ANTXR2 Protein, Human (HEK293, Fc) anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2	Human	HEK293
	CMG-2/ANTXR2 is essential for cellular interactions with laminin and the extracellular matrix. As a receptor for the protective antigen (PA) of B. anthracis, it undergoes heptamerization upon PA binding. The complex is internalized through a clathrin-dependent pathway, and in the endosomal membrane (pH < 7), it rearranges to form a pore, facilitating the entry of other components of anthrax toxin into the cytoplasm. CMG-2/ANTXR2 Protein, Human (HEK293, Fc) is the recombinant human-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CMG-2/ANTXR2 Protein, Human (HEK293, Fc) is 317 a.a., with molecular weight of ~57.4 KDa.

	CMG-2/ANTXR2 Protein, Mouse (HEK293, Fc) anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2	Mouse	HEK293
	CMG-2/ANTXR2 is essential for cell adhesion and communication with laminin and the extracellular matrix. It exhibits specific binding to laminin, emphasizing its role in laminin-dependent cellular processes. CMG-2/ANTXR2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CMG-2/ANTXR2 Protein, Mouse (HEK293, Fc) is 318 a.a., with molecular weight of ~57.9 KDa.

	CMG-2/ANTXR2 Protein, Mouse (HEK293, His) anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2	Mouse	HEK293
	CMG-2/ANTXR2 is essential for cell adhesion and communication with laminin and the extracellular matrix. It exhibits specific binding to laminin, emphasizing its role in laminin-dependent cellular processes. CMG-2/ANTXR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CMG-2/ANTXR2 Protein, Mouse (HEK293, His) is 318 a.a., with molecular weight of ~32 KDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81315

Anthrax Protective gen Antibody (YA1060)

Protective antigen
ELISA Bacillusanthracis

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