Hexa-D-arginine TFA (Synonyms: Furin Inhibitor II TFA)

Name: Hexa-D-arginine TFA
Brand: MedChemExpress
SKU: HY-P1028A
Rating: 5.0 (6 reviews)

Cat. No.: HY-P1028A Purity: 99.01%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Hexa-D-arginine TFA Chemical Structure

CAS No. : 958204-56-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 6 publication(s) in Google Scholar

Other Forms of Hexa-D-arginine TFA:

Hexa-D-arginine In-stock

6 Publications Citing Use of MCE Hexa-D-arginine TFA

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)^[3]

In Vitro

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1068.17

Formula

C₃₈H₇₆F₃N₂₅O₈

CAS No.

958204-56-3

Appearance

Solid

Color

White to off-white

Sequence

d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2

Sequence Shortening

d(RRRRRR)-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (46.81 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9362 mL	4.6809 mL	9.3618 mL
5 mM	0.1872 mL	0.9362 mL	1.8724 mL
10 mM	0.0936 mL	0.4681 mL	0.9362 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (281 KB) SDS (254 KB)

COA (260 KB) RP-HPLC (112 KB) MS (192 KB) Elemental Analysis Report (119 KB)

Handling Instructions (2659 KB)

References

[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [Content Brief]

[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [Content Brief]

[3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.9362 mL	4.6809 mL	9.3618 mL	23.4045 mL
	5 mM	0.1872 mL	0.9362 mL	1.8724 mL	4.6809 mL
	10 mM	0.0936 mL	0.4681 mL	0.9362 mL	2.3405 mL
	15 mM	0.0624 mL	0.3121 mL	0.6241 mL	1.5603 mL
	20 mM	0.0468 mL	0.2340 mL	0.4681 mL	1.1702 mL
	25 mM	0.0374 mL	0.1872 mL	0.3745 mL	0.9362 mL
	30 mM	0.0312 mL	0.1560 mL	0.3121 mL	0.7802 mL
	40 mM	0.0234 mL	0.1170 mL	0.2340 mL	0.5851 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Hexa-D-arginine TFA Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexa-D-arginine958204-56-3Furin Inhibitor IIBacterialTNF-αPEAfurinnoncytotoxicanthraxexotoxinsPC1PACE4Inhibitorinhibitorinhibit

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Hexa-D-arginine TFA (Synonyms: Furin Inhibitor II TFA)

Customer Review

Other Forms of Hexa-D-arginine TFA:

Hexa-D-arginine TFA Related Antibodies

6 Publications Citing Use of MCE Hexa-D-arginine TFA

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Hexa-D-arginine TFA Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Hexa-D-arginine TFA Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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