Hexa-D-arginine TFA
Based on 6 publication(s) in Google Scholar
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.
For research use only. We do not sell to patients.
- Purity: 99.01%
- CAS No.: 958204-56-3
- Formula: C38H76F3N25O8
- Molecular Weight:1068.17
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hexa-D-arginine TFA
More
Biological Activity
Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 958204-56-3
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Appearance Solid
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Molecular Weight 1068.17
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Formula C38H76F3N25O8
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Color White to off-white
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Synonyms
Furin Inhibitor II TFA
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Sequence
d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2
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Sequence Shortening
d(RRRRRR)-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation. [Abstract]2025 Mar 20:e2415007. PMID: 40112179 -
Oncogenesis
Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells. [Abstract]2020 Aug 26;9(8):76. PMID: 32848128 -
Antiviral Res
Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2. [Abstract]2023 Jun:214:105606. PMID: 37076089 -
Chembiochem
Targeted Delivery of an Activatable Fluorescent Probe for the Detection of Furin Activity in Living Cells. [Abstract]2018 May 18;19(10):1060-1065. PMID: 29465834 -
Solvent & Solubility
H2O : 50 mg/mL (46.81 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [Content Brief]
[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [Content Brief]
[3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9362 mL | 4.6809 mL | 9.3618 mL | 23.4045 mL |
| 5 mM | 0.1872 mL | 0.9362 mL | 1.8724 mL | 4.6809 mL | |
| 10 mM | 0.0936 mL | 0.4681 mL | 0.9362 mL | 2.3405 mL | |
| 15 mM | 0.0624 mL | 0.3121 mL | 0.6241 mL | 1.5603 mL | |
| 20 mM | 0.0468 mL | 0.2340 mL | 0.4681 mL | 1.1702 mL | |
| 25 mM | 0.0374 mL | 0.1872 mL | 0.3745 mL | 0.9362 mL | |
| 30 mM | 0.0312 mL | 0.1560 mL | 0.3121 mL | 0.7802 mL | |
| 40 mM | 0.0234 mL | 0.1170 mL | 0.2340 mL | 0.5851 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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