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  2. Hexa-D-arginine TFA

Hexa-D-arginine TFA (Synonyms: Furin Inhibitor II TFA)

Cat. No.: HY-P1028A
Handling Instructions

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

For research use only. We do not sell to patients.

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Hexa-D-arginine TFA Chemical Structure

Hexa-D-arginine TFA Chemical Structure

CAS No. : 958204-56-3

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Description

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

IC50 & Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]

In Vitro

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].

In Vivo

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].

Molecular Weight

1068.17

Formula

C₃₈H₇₆F₃N₂₅O₈

CAS No.

958204-56-3

Sequence

Arg-Arg-Arg-Arg-Arg-Arg-NH2

Sequence Shortening

RRRRRR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Hexa-D-arginineFurin Inhibitor IIOthersTNF-αPEAfurinnoncytotoxicanthraxexotoxinsPC1PACE4Inhibitorinhibitorinhibit

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Hexa-D-arginine TFA
Cat. No.:
HY-P1028A
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