Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

  • Infect Immun. 2004 Jan;72(1):602-5. doi: 10.1128/IAI.72.1.602-605.2004.
Miroslav S Sarac  1 ,  Juan R Peinado ,  Stephen H Leppla ,  Iris Lindberg
Affiliations
  • 1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
PMID: 14688144 DOI: 10.1128/IAI.72.1.602-605.2004
Abstract

The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by Furin or a furin-like protease. We present here data demonstrating that the small stable Furin Inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live Animals, suggesting that Furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.

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