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Hexa-D-arginine (Synonyms: Furin Inhibitor II)

Cat. No.: HY-P1028 Purity: 99.57%
Handling Instructions

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

For research use only. We do not sell to patients.

Hexa-D-arginine Chemical Structure

Hexa-D-arginine Chemical Structure

CAS No. : 673202-67-0

Size Price Stock Quantity
1 mg USD 114 In-stock
Estimated Time of Arrival: December 31
5 mg USD 456 In-stock
Estimated Time of Arrival: December 31
10 mg USD 816 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Hexa-D-arginine:

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Description

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

IC50 & Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]

In Vitro

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

954.14

Formula

C₃₆H₇₅N₂₅O₆

CAS No.

673202-67-0

Sequence Shortening

RRRRRR-NH2

SMILES

O=C([[email protected]@H](CCCNC(N)=N)NC([[email protected]@H](CCCNC(N)=N)NC([[email protected]](N)CCCNC(N)=N)=O)=O)N[[email protected]](CCCNC(N)=N)C(N[[email protected]](CCCNC(N)=N)C(N[[email protected]@H](C(N)=O)CCCNC(N)=N)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (52.40 mM; Need ultrasonic)

DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0481 mL 5.2403 mL 10.4806 mL
5 mM 0.2096 mL 1.0481 mL 2.0961 mL
10 mM 0.1048 mL 0.5240 mL 1.0481 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.57%

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Keywords:

Hexa-D-arginineFurin Inhibitor IIOthersTNF-αPEAfurinnoncytotoxicanthraxexotoxinsPC1PACE4Inhibitorinhibitorinhibit

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Hexa-D-arginine
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HY-P1028
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