Hexa-D-arginine
Based on 7 publication(s) in Google Scholar
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 673202-67-0
- Formula: C36H75N25O6
- Molecular Weight:954.14
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hexa-D-arginine
More
Biological Activity
Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 673202-67-0
-
Appearance Solid
-
Molecular Weight 954.14
-
Formula C36H75N25O6
-
Color White to off-white
-
Synonyms
Furin Inhibitor II
-
Sequence
d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2
-
Sequence Shortening
d(RRRRRR)-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
-
Adv Sci (Weinh)
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation. [Abstract]2025 Mar 20:e2415007. PMID: 40112179 -
Phytomedicine
Licochalcone B alleviates pulmonary vascular remodeling via inhibiting Furin/TGF-β1 in pulmonary hypertension. [Abstract]2026 Aug:158:158373. PMID: 42263545 -
Oncogenesis
Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells. [Abstract]2020 Aug 26;9(8):76. PMID: 32848128 -
Antiviral Res
Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2. [Abstract]2023 Jun:214:105606. PMID: 37076089 -
Chembiochem
Targeted Delivery of an Activatable Fluorescent Probe for the Detection of Furin Activity in Living Cells. [Abstract]2018 May 18;19(10):1060-1065. PMID: 29465834 -
Solvent & Solubility
H2O : 50 mg/mL (52.40 mM; Need ultrasonic)
DMSO : 5 mg/mL (5.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (104.81 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [Content Brief]
[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [Content Brief]
[3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.0481 mL | 5.2403 mL | 10.4806 mL | 26.2016 mL |
| 5 mM | 0.2096 mL | 1.0481 mL | 2.0961 mL | 5.2403 mL | |
| H2O | 10 mM | 0.1048 mL | 0.5240 mL | 1.0481 mL | 2.6202 mL |
| 15 mM | 0.0699 mL | 0.3494 mL | 0.6987 mL | 1.7468 mL | |
| 20 mM | 0.0524 mL | 0.2620 mL | 0.5240 mL | 1.3101 mL | |
| 25 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0481 mL | |
| 30 mM | 0.0349 mL | 0.1747 mL | 0.3494 mL | 0.8734 mL | |
| 40 mM | 0.0262 mL | 0.1310 mL | 0.2620 mL | 0.6550 mL | |
| 50 mM | 0.0210 mL | 0.1048 mL | 0.2096 mL | 0.5240 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hexa-D-arginine Related Classifications
HY-P1028 Related Classifications
Powered by Bioz