673202-67-0
Chemical Structure
Hexa-D-arginine
Synonym(s): Furin Inhibitor II
- CAS. Nr.: 673202-67-0
- Formula:C36H75N25O6
- Molecular Weight:954.14
IUPAC Name: (R)-2-amino-N-((6R,9R,12R,15R,18R)-1,23-diamino-6-carbamoyl-9,12,15-tris(3-guanidinopropyl)-1,23-diimino-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosan-18-yl)-5-guanidinopentanamide
InChIKey: BMLTZEAFQLJTIZ-TZNXUKFXSA-N
SMILES: O=C([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O
Biological Activity: Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].
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Hexa-D-arginine | 99.97% | Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo. | ||||||||||||||||||||
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References
- [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [Content Brief]
- [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [Content Brief]
- [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. [Content Brief]
