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Cat. No.: HY-P10150

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IN-2-LF

IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R.

For research use only. We do not sell to patients.

CAS No.: 749879-64-9
Formula: C₈₁H₁₅₀N₄₂O₁₇
Molecular Weight:1984.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IN-2-LF Chemical Structure

CAS No.: 749879-64-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R^[1].

Chemical Information

CAS No. 749879-64-9
Molecular Weight 1984.33
Formula C₈₁H₁₅₀N₄₂O₁₇
Sequence

Ac-Gly-Tyr-{Bal}-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
Sequence Shortening

Ac-GY-{Bal}-RRRRRRRRVLR-NHOH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Peinado JR, et al. Cross-inhibition between furin and lethal factor inhibitors. Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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