Raxibacumab
Based on 1 Customer Validation
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research.
For research use only. We do not sell to patients.
- Purity: 98.88%
- CAS No.: 565451-13-0
- Molecular Weight:142.96 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 lambda
Human
anthrax protective antigen
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:In SD rats after the initiation of a 24-h LeTx infusion[3]
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Dosage:150 μg/kg or 300 μg/kg
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Administration:At the time of or 3, 6, 9, or 12 h after the initiation of LeTx infusion, the rats were randomized to be treated i.v. in a single dose
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Result:Significantly improved in outcome when it was administered up to 6 h (and approached significance when administered up to 12 h) after initial exposure to LeTx.
Rats receiving raxibacumab within 6 hours of toxin administration had a better survival rate than those that received raxibacumab at 9 or 12 hours.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
45025512 [NCBI]
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 lambda
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 565451-13-0
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Appearance Liquid
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Molecular Weight 142.96 kDa
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Color Colorless to light yellow
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SMILES
[Raxibacumab]
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Synonyms
ABthrax
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Mazumdar S. Raxibacumab. MAbs.2009 Nov-Dec;1(6):531-8. [Content Brief]
[2]. Kummerfeldt CE. Raxibacumab: potential role in the treatment of inhalational anthrax. Infect Drug Resist. 2014 Apr 29;7:101-9. [Content Brief]
[3]. Cui X, et.al. Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis. J Infect Dis. 2005 Feb 1;191(3):422-34. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Raxibacumab Related Classifications
HY-P9957 Related Classifications
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