2. Anti-infection
  3. Bacterial
  4. Raxibacumab

Raxibacumab  (Synonyms: ABthrax)

Cat. No.: HY-P9957 Purity: 98.88%
COA

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Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research.

For research use only. We do not sell to patients.

Raxibacumab Chemical Structure

Raxibacumab Chemical Structure

CAS No. : 565451-13-0

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Description

Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research[1][2].

In Vivo

Raxibacumab (150 μg/kg or 300 μg/kg for i.v., single dose) significantly improved in outcome when it was administered up to 6 h after rats initial exposure to Bacillus anthracis lethal toxin (LeTx) infusion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: In SD rats after the initiation of a 24-h LeTx infusion[3]
Dosage: 150 μg/kg or 300 μg/kg
Administration: At the time of or 3, 6, 9, or 12 h after the initiation of LeTx infusion, the rats were randomized to be treated i.v. in a single dose
Result: Significantly improved in outcome when it was administered up to 6 h (and approached significance when administered up to 12 h) after initial exposure to LeTx.
Rats receiving raxibacumab within 6 hours of toxin administration had a better survival rate than those that received raxibacumab at 9 or 12 hours.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Raxibacumab]
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Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.88%

COA (231 KB)

Handling Instructions (2659 KB)
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Raxibacumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raxibacumab565451-13-0ABthraxBacterialAnthraxBacillus anthracisprotective antigenanti-Anthraxhuman IgG1 monoclonal antibodyInhibitorinhibitorinhibit

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