2. Inhibitory Antibodies
  3. Isotype Control Antibodies
  4. Human IgG1 lambda1, Isotype Control

Human IgG1 lambda1, Isotype Control 

Cat. No.: HY-P99992 Purity: 99.64%
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Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer.

For research use only. We do not sell to patients.

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Based on 2 publication(s) in Google Scholar

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Human IgG1 lambda1, Isotype Control Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Human IgG1 lambda1, Isotype Control

In Vivo Efficacy Study
Bio/Physico-chemical Assay
Histological Imaging/Staining

    Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654.  [Abstract]

    Pancreatic tumor samples from chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks), or bimagrumab+metformin.

    Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654.  [Abstract]

    Bar graph showing fasting blood glucose changes in diabetic tumor-bearing mice after treatment with 2 doses of IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), 2 doses of bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) alone, or 2 doses of bimagrumab combined with 7 doses of metformin (n = 9 mice per group).

    Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654.  [Abstract]

    Representative images and quantification of α-SMA staining (brown) in tumors from chow and diabetic KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks) or bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) (n = 6 mice per group).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer[1][2].

    In Vitro

    Human IgG1 lambda1, Isotype Control (48 h before supernatant collection) can be used in macrophages as a control for the inhibitory effect of the human OLR1 blocking antibody Golocdacimab (HY-P99646) on OLR1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Human IgG1 lambda1, Isotype Control Related Antibodies
    In Vivo

    Human IgG1 lambda1, Isotype Control (20 mg/kg, s.c., once weekly; two doses) can be used as a control for Bimagrumab (HY-P99355) in diabetic pancreatic cancer mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    141.84 kDa

    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Human IgG1 lambda1, Isotype Control]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 99.64%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (66 KB) SEC-HPLC (89 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Human IgG1 lambda1, Isotype Control Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Human IgG1 lambda1, Isotype ControlOthersdiabetic pancreatic cancermiceInhibitorinhibitorinhibit

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