CMG-2/ANTXR2 Protein, Mouse (HEK293, His)
Based on 1 Customer Validation
CMG-2/ANTXR2 is essential for cell adhesion and communication with laminin and the extracellular matrix. It exhibits specific binding to laminin, emphasizing its role in laminin-dependent cellular processes. CMG-2/ANTXR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CMG-2/ANTXR2 is essential for cell adhesion and communication with laminin and the extracellular matrix. It exhibits specific binding to laminin, emphasizing its role in laminin-dependent cellular processes. CMG-2/ANTXR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-His labeled tag.
Background
CMG-2/ANTXR2 protein is indispensable for cellular interactions with laminin and the extracellular matrix, indicating its pivotal role in mediating adhesion and communication between cells and their surrounding environment. This protein exhibits a specific binding affinity for laminin, emphasizing its involvement in the regulation of laminin-dependent cellular processes. Furthermore, there is a suggestion of potential interaction with collagen type IV, broadening its scope of engagement with key components of the extracellular matrix. The capacity of CMG-2/ANTXR2 to bind to laminin and possibly collagen type IV underscores its significance in cellular adhesion and matrix-related functions, contributing to the intricate framework of cellular interactions within tissues.
Verified Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized anthrax protective antigen (PA) at 1.5 µg/mL can bind Mouse CMG-2. The ED50 for this effect is 1.329 μg/mL.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
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Bioactivity - ELISA
Bioactivity - ELISA
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-His
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Accession
Q6DFX2 (Q32-G318)
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Molecular Construction
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N-term
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CMG-2 (Q32-G318)
Accession # Q6DFX2 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
ANTXR2; FLJ31074; ANTXR Cell Adhesion Molecule 2; Anthrax Toxin Receptor 2, Isoform CRA_c; CMG-2; Anthrax Toxin Receptor; CMG2; ANTXR2 Protein; Anthrax Toxin Receptor 2; HFS; Capillary Morphogenesis Gene 2 Protein; ISH; Capillary Morphogenesis Protein 2;
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AA Sequence
QAQEQPSCKKAFDLYFVLDKSGSVANNWIEIYNFVHQLTERFVSPEMRLSFIVFSSQATIILPLTGDRYKIGKGLEDLKAVKPVGETYIHEGLKLANEQIQNAGGLKASSIIIALTDGKLDGLVPSYAENEAKKSRSLGASVYCVGVLDFEQAQLERIADSKDQVFPVKGGFQALKGIINSILAQSCTEILELSPSSVCVGEKFQVVLTGRAVTSISHDGSVLCTFTANSTYTKSEKPVSIQPSSILCPAPVLNKDGETLEVSISYNDGKSAVSRSLTITATECTNG
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Molecular Weight
Approximately 34 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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