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Art. -Nr.: HY-180145

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Furin-IN-3

Furin-IN-3 is a non-peptidic furin inhibitor with a dichlorobiphenyl-derived core, with a K_i value of 1.67 nM for furin inhibition and a K_i value of 278 nM for proprotein convertase PC7 inhibition. Furin-IN-3 can be used in the research of influenza A virus infection (H7N7 strain SC35M).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3080672-14-3
Formel: C₃₈H₄₇Cl₂F₉N₄O₇
Molecular Weight:913.69

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Furin-IN-3 Chemical Structure

CAS. Nr.: 3080672-14-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

furin

1.67 nM (Ki)

PC7

278 nM (Ki)

In Vitro

Furin-IN-3 (compound 9) inhibits furin with a K_ivalue of 12.4 nM in a fluorogenic substrate assay, indicating that it ranks among the moderately potent inhibitors in this series [1].
Furin-IN-3 inhibits PC7 with a K_i value of 278 nM, indicating that it exhibits significantly weaker activity against this related proprotein convertase than against furin^[1].
Furin-IN-3 (72 h) demonstrates the most potent antiviral activity against the H7N7 influenza strain SC35M in A549 cells at 5 μM, reducing viral titers by 10⁴ to 10⁵-fold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3080672-14-3
Molecular Weight 913.69
Formel C₃₈H₄₇Cl₂F₉N₄O₇
SMILES

O=C(C(F)(F)F)O.O=C(C)NCC1CCN(CC1)CC2=CC(C3=CC(Cl)=CC(Cl)=C3)=CC(CN4CCC(C5CCNCC5)CC4)=C2.O=C(C(F)(F)F)O.O=C(C(F)(F)F)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lange RW, et al. Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin. Journal of medicinal chemistry. 2025 Dec 11;68(23):25157-25170. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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