Furin-IN-3

Furin-IN-3 (Compound 9) is a potent and selective proprotein convertase furin inhibitor with a K_i of 12.4 nM. Furin-IN-3 shows a K_i of 278 nM for PC7. Furin-IN-3 shows a significant antiviral effect on the Furin-dependent H7N7 influenza A virus strain SC35M. Furin-IN-3 can inhibit the cleavage and activation of the viral hemagglutinin (HA), prevent the fusion of the viral membrane with the host cell membrane, and thereby inhibit viral replication and proliferation. Furin-IN-3 can be used for the research of infection, such as influenza virus infection.

• Data Sheet (266 KB)