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Cat. No.: HY-P5062A

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DEC-RVRK-CMK TFA

Name: DEC-RVRK-CMK TFA
Brand: MedChemExpress
SKU: HY-P5062A
Price: 220.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA)

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DEC-RVRK-CMK TFA (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK TFA is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK TFA inhibits PC4-mediated proteolysis with an IC₅₀ of 12.2 nM in rats. DEC-RVRK-CMK TFA holds promise for antiviral infection-related research.

For research use only. We do not sell to patients.

Purity : 99.04%
Formula: C₃₄H₆₆ClN₁₁O₅._xC₂HF₃O₂
Molecular Weight:744.41 (free base)

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DEC-RVRK-CMK TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

DEC-RVRK-CMK TFA has no inhibitory effect on the cleavage conversion of ADAM2 protein from 46 kDa to 27 kDa during sperm capacitation, whereas the broad-spectrum kexin-like convertase inhibitor dec-RVKR-CMK (HY-107760) can block this processing, indicating that this cleavage is mediated by other members of the PCSK family such as PCSK7 and is independent of PCSK4^[1].
DEC-RVRK-CMK TFA (RVRK) (10 μM; 24-48 h) does not inhibit branching morphogenesis of E15 rat SMG rudiments in organ culture or reduce AQP5 expression^[4].
DEC-RVRK-CMK TFA (1 h) blocks proconvertase-mediated cleavage of inhibin α- and βB-subunits in LβT2 pituitary gonadotrope cells, leading to accumulation of unprocessed pro-αN-αC and pro-βB^[2].
DEC-RVRK-CMK TFA inhibits purified recombinant rat PC4 (rec-rPC4-FLV5 E1-pool) with an IC₅₀ of 12.2 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

Appearance Solid
Molecular Weight 744.41 (free base)
Formula C₃₄H₆₆ClN₁₁O₅._xC₂HF₃O₂
Color White to off-white
Synonyms

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA
Sequence

{DEC}-Arg-Val-Arg-Lys-{CMK}
Sequence Shortening

{DEC}-RVRK-{CMK}
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 5 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gyamera-Acheampong C, et al. PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Fertility and sterility. 2010 Mar 01;93(4):1112-23.

[2]. Antenos M, et al. An activin/furin regulatory loop modulates the processing and secretion of inhibin α-and βB-subunit dimers in pituitary gonadotrope cells. Journal of Biological Chemistry. 2008 Nov 28;283(48):33059-68.

[3]. Basak A, et al. Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design. Protein expression and purification. 2008 Aug;60(2):117-26.

[4]. Akamatsu T, et al. Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland. Developmental biology. 2009 Jan 15;325(2):434-43.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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