Decanoyl-RVKR-CMK
Based on 1 publication(s) in Google Scholar
Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 150113-99-8
- Formula: C34H66ClN11O5
- Molecular Weight:744.41
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Decanoyl-RVKR-CMK
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
11.5 μM
Compound: Dec-RVKR-CMK
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Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay
Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay
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[PMID: 24359257] |
Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].
Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.
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Concentration:35 and 70 µΜ.
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Incubation Time:7 days.
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Result:Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
Chemical Information
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CAS No. 150113-99-8
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Appearance Solid
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Molecular Weight 744.41
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Formula C34H66ClN11O5
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Color White to off-white
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Synonyms
DecRVKRcmk
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
2023 Nov 10;19(11):e1011789. PMID: 37948454
Solvent & Solubility
DMSO : 100 mg/mL (134.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [Content Brief]
[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3433 mL | 6.7167 mL | 13.4335 mL | 33.5836 mL |
| 5 mM | 0.2687 mL | 1.3433 mL | 2.6867 mL | 6.7167 mL | |
| 10 mM | 0.1343 mL | 0.6717 mL | 1.3433 mL | 3.3584 mL | |
| 15 mM | 0.0896 mL | 0.4478 mL | 0.8956 mL | 2.2389 mL | |
| 20 mM | 0.0672 mL | 0.3358 mL | 0.6717 mL | 1.6792 mL | |
| 25 mM | 0.0537 mL | 0.2687 mL | 0.5373 mL | 1.3433 mL | |
| 30 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1195 mL | |
| 40 mM | 0.0336 mL | 0.1679 mL | 0.3358 mL | 0.8396 mL | |
| 50 mM | 0.0269 mL | 0.1343 mL | 0.2687 mL | 0.6717 mL | |
| 60 mM | 0.0224 mL | 0.1119 mL | 0.2239 mL | 0.5597 mL | |
| 80 mM | 0.0168 mL | 0.0840 mL | 0.1679 mL | 0.4198 mL | |
| 100 mM | 0.0134 mL | 0.0672 mL | 0.1343 mL | 0.3358 mL |
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