Decanoyl-RVKR-CMK TFA (Synonyms: DecRVKRcmk TFA)

Name: Decanoyl-RVKR-CMK TFA
Brand: MedChemExpress
SKU: HY-107760A
Rating: 4.5 (1 reviews)

Cat. No.: HY-107760A Purity: 97.08%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Decanoyl-RVKR-CMK TFA 화학구조

CAS No. : 2098497-25-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Decanoyl-RVKR-CMK TFA:

Decanoyl-RVKR-CMK In-stock

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK TFA

•PLoS Pathog. 2023 Nov 10;19(11):e1011789. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

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HIV HIV-1 HIV-2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication^[1].

IC₅₀ & Target

HIV-1

HIV-2

In Vitro

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits HIV-2_ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell^[1].
? Decanoyl-RVKR-CMK (DecRVKRcmk) TFA blocks regulated secretion of VGF^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL
Concentration:	35 and 70 µΜ
Incubation Time:	7 days
Result:	Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).

분자량

858.43

화학식

C₃₆H₆₇ClF₃N₁₁O₇

CAS No.

2098497-25-5

Appearance

Solid

Color

White to off-white

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (116.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4 mg/mL (4.66 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1649 mL	5.8246 mL	11.6492 mL
5 mM	0.2330 mL	1.1649 mL	2.3298 mL
10 mM	0.1165 mL	0.5825 mL	1.1649 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.04%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (247 KB) RP-HPLC (111 KB) MS (224 KB)

Handling Instructions (2659 KB)

References

[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [Content Brief]

[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.1649 mL	5.8246 mL	11.6492 mL	29.1229 mL
DMSO	5 mM	0.2330 mL	1.1649 mL	2.3298 mL	5.8246 mL
	10 mM	0.1165 mL	0.5825 mL	1.1649 mL	2.9123 mL
	15 mM	0.0777 mL	0.3883 mL	0.7766 mL	1.9415 mL
	20 mM	0.0582 mL	0.2912 mL	0.5825 mL	1.4561 mL
	25 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1649 mL
	30 mM	0.0388 mL	0.1942 mL	0.3883 mL	0.9708 mL
	40 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.7281 mL
	50 mM	0.0233 mL	0.1165 mL	0.2330 mL	0.5825 mL
	60 mM	0.0194 mL	0.0971 mL	0.1942 mL	0.4854 mL
	80 mM	0.0146 mL	0.0728 mL	0.1456 mL	0.3640 mL
	100 mM	0.0116 mL	0.0582 mL	0.1165 mL	0.2912 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Decanoyl-RVKR-CMK TFA Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decanoyl-RVKR-CMK2098497-25-5DecRVKRcmkHIVHuman immunodeficiency virusglycoproteinVGF glycoproteinVGFHIV-2 ROD infectionreplicationInhibitorinhibitorinhibit

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Decanoyl-RVKR-CMK TFA (Synonyms: DecRVKRcmk TFA)

고객리뷰

Other Forms of Decanoyl-RVKR-CMK TFA:

Decanoyl-RVKR-CMK TFA Related Antibodies

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK TFA

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Decanoyl-RVKR-CMK TFA Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Decanoyl-RVKR-CMK TFA Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report