Decanoyl-RVKR-CMK TFA
Based on 1 publication(s) in Google Scholar
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication.
For research use only. We do not sell to patients.
- Purity: 97.53%
- CAS No.: 2098497-25-5
- Formula: C36H67ClF3N11O7
- Molecular Weight:858.43
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Decanoyl-RVKR-CMK TFA
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Biological Activity
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HIV-1 |
HIV-2 |
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].
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Decanoyl-RVKR-CMK (DecRVKRcmk) TFA blocks regulated secretion of VGF[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL
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Concentration:35 and 70 µΜ
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Incubation Time:7 days
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Result:Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
Chemical Information
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CAS No. 2098497-25-5
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Appearance Solid
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Molecular Weight 858.43
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Formula C36H67ClF3N11O7
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Color White to off-white
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Synonyms
DecRVKRcmk TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
2023 Nov 10;19(11):e1011789. PMID: 37948454
Solvent & Solubility
DMSO : 100 mg/mL (116.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 4 mg/mL (4.66 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [Content Brief]
[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.1649 mL | 5.8246 mL | 11.6492 mL | 29.1229 mL |
| DMSO | 5 mM | 0.2330 mL | 1.1649 mL | 2.3298 mL | 5.8246 mL |
| 10 mM | 0.1165 mL | 0.5825 mL | 1.1649 mL | 2.9123 mL | |
| 15 mM | 0.0777 mL | 0.3883 mL | 0.7766 mL | 1.9415 mL | |
| 20 mM | 0.0582 mL | 0.2912 mL | 0.5825 mL | 1.4561 mL | |
| 25 mM | 0.0466 mL | 0.2330 mL | 0.4660 mL | 1.1649 mL | |
| 30 mM | 0.0388 mL | 0.1942 mL | 0.3883 mL | 0.9708 mL | |
| 40 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.7281 mL | |
| 50 mM | 0.0233 mL | 0.1165 mL | 0.2330 mL | 0.5825 mL | |
| 60 mM | 0.0194 mL | 0.0971 mL | 0.1942 mL | 0.4854 mL | |
| 80 mM | 0.0146 mL | 0.0728 mL | 0.1456 mL | 0.3640 mL | |
| 100 mM | 0.0116 mL | 0.0582 mL | 0.1165 mL | 0.2912 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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