1. Anti-infection
  2. Bacterial Antibiotic
  3. Cilastatin sodium

Cilastatin sodium  (Synonyms: MK0791 sodium)

Cat. No.: HY-A0166A Purity: 98.84%
COA Handling Instructions

Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct.

For research use only. We do not sell to patients.

Cilastatin sodium Chemical Structure

Cilastatin sodium Chemical Structure

CAS No. : 81129-83-1

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Cilastatin sodium:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3].

IC50 & Target

β-lactam

 

In Vitro

Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Renal proximal tubular epithelial cells (RPTECs)
Concentration: 200 μg/mL
Incubation Time: 24 hours
Result: Significantly ameliorated Vancomycin-induced nuclear apoptosis.
In Vivo

In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus, E. coli, and P. aeruginosa infection[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

380.43

Formula

C16H25N2NaO5S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C(NC([C@@H]1C(C)(C)C1)=O)=C/CCCCSC[C@H](N)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (262.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6286 mL 13.1430 mL 26.2860 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL
10 mM 0.2629 mL 1.3143 mL 2.6286 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Cilastatin sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cilastatin sodium
Cat. No.:
HY-A0166A
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