1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cilastatin sodium

Cilastatin sodium (Synonyms: MK0791 sodium)

Cat. No.: HY-A0166A
Handling Instructions

Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct.

For research use only. We do not sell to patients.

Cilastatin sodium Chemical Structure

Cilastatin sodium Chemical Structure

CAS No. : 81129-83-1

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Description

Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3].

IC50 & Target

IC50: 0.1 μM (Renal dehydropeptidase I); 178 μM (Bacterial metallob-lactamase enzyme CphA)[1]

In Vitro

Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin[2].

Apoptosis Analysis[2]

Cell Line: Renal proximal tubular epithelial cells (RPTECs)
Concentration: 200 μg/mL
Incubation Time: 24 hours
Result: Significantly ameliorated Vancomycin-induced nuclear apoptosis.
In Vivo

In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus, E. coli, and P. aeruginosa infection[3].

Molecular Weight

380.43

Formula

C₁₆H₂₅N₂NaO₅S

CAS No.

81129-83-1

SMILES

O=C(O)/C(NC([[email protected]@H]1C(C)(C)C1)=O)=C/CCCCSC[[email protected]](N)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CilastatinMK0791MK 0791MK-0791BacterialAntibioticRenaldehydropeptidasezincpeptidaseCphAmetallob-lactamaseantibacterialadjunctInhibitorinhibitorinhibit

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Cilastatin sodium
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HY-A0166A
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